Pharmacokinetic study of ketoprofen (19.583 R.P.) in man using the tritiated compound.

@article{Delbarre1976PharmacokineticSO,
  title={Pharmacokinetic study of ketoprofen (19.583 R.P.) in man using the tritiated compound.},
  author={F. Delbarre and J. C. Roucayrol and B. El Hadi Amor and J C Ingrand and G Bourat and Jacques Fournel and J Courjaret},
  journal={Scandinavian journal of rheumatology. Supplement},
  year={1976},
  volume={1976 0},
  pages={45-52}
}
Ketoprofen (19.583 R. P., Profenid N. D., Orudis) labelled with tritium was administered orally to 4 patients (3 men - 1 woman) at a dose of 150 mg (therapeutic dose) with a radioactivity of approximately 500 muCi. Tritiated ketoprofen capsules, which disintegrated in the stomach, were administered in particle size of the same order as in the clinical trial material. The ketoprofen plasma levels and the quantities of the compound excreted in the urine and faeces were measured for 5 days after… CONTINUE READING