Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk

@article{Saux2010PharmacokineticSO,
  title={Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk},
  author={Marie Claude Saux and J. Mosser and Henri Pontagnier and Bingshuang Leng},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={8},
  pages={43-49}
}
  • M. Saux, J. Mosser, B. Leng
  • Published 2010
  • Chemistry, Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryPharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or not 200 ml of whole milk. Ingestion of milk had only mild effect upon absorption parameters of doxycycline; only a moderate increase of the lag-time was significant. Elimination parameters of doxycycline were impaired by milk; a decrease of the terminal half-life from 28 h to 15 h, an apparent… 
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