Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk

  title={Pharmacokinetic study of doxycycline polyphosphate after simultaneous ingestion of milk},
  author={Marie Claude Saux and J. Mosser and Henri Pontagnier and Bingshuang Leng},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  • M. Saux, J. Mosser, B. Leng
  • Published 2010
  • Chemistry, Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryPharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or not 200 ml of whole milk. Ingestion of milk had only mild effect upon absorption parameters of doxycycline; only a moderate increase of the lag-time was significant. Elimination parameters of doxycycline were impaired by milk; a decrease of the terminal half-life from 28 h to 15 h, an apparent… 
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Pharmacokinetics of doxycycline polyphosphate after oral multiple dosing in humans
Nine healthy volunteers received oral multiple doses of doxycycline polyphosphate for 6 days to determine the best protocol for producing effective serum antibiotic levels during a complete period of treatment with the aid of a mathematical simulation programme.
Pharmacokinetic study of doxycycline polyphosphate (PPD), Hydrochloride (CHD) and base (DB)
F Fluorimetric analysis of some of the samples confirmed the values obtained, with the exception of a few parameters such as Vd and clearance, which were lower.
Remarques sur l'emploi de la Doxycycline chez l'homme en insuffisance renale, Nouv
  • Presse. Med
  • 1979
Pharmacokinetics of doxycycline polyphosphate, hydrochloride and base. International Symposium on antibiotics and hospital. Milan
  • 1978
Algorithm for least square estimation of non linear parameters
  • J. Soc. Ind. Appl. Mathematics,
  • 1963
An Algorithm for Least-Squares Estimation of Nonlinear Parameters