Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride

@article{Xie2014PharmacokineticSO,
  title={Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride},
  author={Feifan Xie and Zeneng Cheng and Sanwang Li and Xingling Liu and Xin Guo and Peng Yu and Zhenkun Gu},
  journal={The Journal of Clinical Pharmacology},
  year={2014},
  volume={54}
}
Benfotiamine is a lipid‐soluble thiamine precursor which can transform to thiamine in vivo and subsequently be metabolized to thiamine monophosphate (TMP) and thiamine diphosphate (TDP). This study investigated the pharmacokinetic profiles of thiamine and its phosphorylated metabolites after single‐ and multiple‐dose administration of benfotiamine in healthy Chinese volunteers, and assessed the bioavailability of orally benfotiamine administration compared to thiamine hydrochloride. In addition… Expand
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