Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin.

@article{Hambleton2002PharmacokineticSO,
  title={Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin.},
  author={Julie Hambleton and David J Wages and Lucian Radu-Radulescu and Melanie R Adams and Malcolm R. Mackenzie and S. James Shafer and Martin M. S. Lee and Jocelyn Smyers and Gary Wiesehahn and Laurence Corash},
  journal={Transfusion},
  year={2002},
  volume={42 10},
  pages={1302-7}
}
BACKGROUND To date, no clinical trials have characterized FFP infusion efficacy, and infusion still carries infectious risk. This single-blinded crossover study compared postinfusion kinetics of FVII in photochemically treated FFP to standard FFP. STUDY DESIGN AND METHODS Subjects donated plasma by apheresis. Half of the collected plasma was treated with the psoralen amotosalen hydrochloride (S-59) and UVA light, and half were prepared as standard plasma. Subjects received warfarin over 4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…