Pharmacokinetic strategies for treatment of drug overdose and addiction.

@article{Gorelick2012PharmacokineticSF,
  title={Pharmacokinetic strategies for treatment of drug overdose and addiction.},
  author={D. Gorelick},
  journal={Future medicinal chemistry},
  year={2012},
  volume={4 2},
  pages={
          227-43
        }
}
  • D. Gorelick
  • Published 2012
  • Medicine
  • Future medicinal chemistry
The pharmacokinetic treatment strategy targets the drug molecule itself, aiming to reduce drug concentration at the site of action, thereby minimizing any pharmacodynamic effect. This approach might be useful in the treatment of acute drug toxicity/overdose and in the long-term treatment of addiction. Phase IIa controlled clinical trials with anticocaine and antinicotine vaccines have shown good tolerability and some efficacy, but Phase IIb and III trials have been disappointing because of the… Expand
Agonist Medications for the Treatment of Cocaine Use Disorder
A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior
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References

SHOWING 1-10 OF 74 REFERENCES
Pharmacokinetic approaches to treatment of drug addiction
  • D. Gorelick
  • Medicine
  • Expert review of clinical pharmacology
  • 2008
Immunopharmacotherapeutic manifolds and modulation of cocaine overdose
Prevention of drug-induced memory impairment by immunopharmacotherapy.
...
1
2
3
4
5
...