Pharmacokinetic relationships between cinromide and its metabolites in the rhesus monkey I: 3-Bromocinnamamide, an active metabolite.

@article{Lane1983PharmacokineticRB,
  title={Pharmacokinetic relationships between cinromide and its metabolites in the rhesus monkey I: 3-Bromocinnamamide, an active metabolite.},
  author={E. Lane and R. Levy},
  journal={Journal of pharmaceutical sciences},
  year={1983},
  volume={72 5},
  pages={
          493-6
        }
}
  • E. Lane, R. Levy
  • Published 1983
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
Fifty percent of a cinromide dose was metabolized to an active metabolite in the rhesus monkey. The steady-state concentration of this metabolite was 3-6 times that of the parent drug, depending on the route of administration. Cinromide is a medium-extraction ratio drug with a short half-life (0.92 +/- 0.23 hr) when compared with the active metabolite, which has a low extraction ratio and a longer half-life (4.43 +/- 0.76 hr). Incomplete oral bioavailability of cinromide is a result of first… Expand
Fractions metabolized in a triangular metabolic system: Cinromide and two metabolites in the rhesus monkey
  • E. Lane, R. Levy
  • Biology, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 2005

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