Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.

  title={Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.},
  author={Harin A. Karunajeewa and Sam Salman and Ivo Mueller and Francisca Baiwog and Servina Gomorrai and Irwin Law and Madhu Page-Sharp and Stephen J Rogerson and Peter Siba and Kenneth F. Ilett and Timothy M E Davis},
  journal={Antimicrobial agents and chemotherapy},
  volume={53 10},
To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were given a single dose of 1,500 mg of SDOX plus 75 mg of pyrimethamine PYR. Blood was taken at baseline and 1, 2, 4, 6, 12, 18, 24, 30, 48, and 72 h and at 7, 10, 14, 28, and 42 days posttreatment in all… CONTINUE READING
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