Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers.

@article{Darwish2006PharmacokineticPO,
  title={Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers.},
  author={Mona Darwish and M Todd Kirby and Philmore Robertson and William G Tracewell and John G. Jiang},
  journal={Clinical therapeutics},
  year={2006},
  volume={28 5},
  pages={707-14}
}
BACKGROUND The fentanyl effervescent buccal tablet (FEBT) is designed to enhance the rate and extent of the absorption of fentanyl, an opioid, through the buccal mucosa. OBJECTIVES The purposes of this study were to assess the dose proportionality of FEBT in healthy volunteers over the potential therapeutic dose range (100-800 microg) and characterize the pharmacokinetic (PK) profile of 4 doses (100, 200, 400, and 800 microg) of FEBT. METHODS This Phase I, randomized, open-label, 4-period… CONTINUE READING

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