Pharmacokinetic properties and metabolism of idebenone

  title={Pharmacokinetic properties and metabolism of idebenone},
  author={Klaus W. Kutz and MSc J{\"u}rgen Drewe and Pierre Vankan},
  journal={Journal of Neurology},
Four phase 1 studies were conducted to assess the pharmacokinetics and metabolism of idebenone (including parent drug and inactive metabolites QS10, QS6, and QS4) and to evaluate the safety of a wide range of idebenone doses and regimens in healthy adult men. After a single oral dose of idebenone 150 mg, 750 mg, or 1050 mg in fasted or fed subjects, blood samples were taken for up to 72 hours. In one study, after a single oral dose and a 7-day washout period, subjects received repeated doses of… CONTINUE READING
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Neurological effects of high-dose idebenone in patients with Friedreich’s ataxia: a randomised, placebo controlled trial

  • NA Di Prospero, A Baker, N Jeaffries, KH Fischbeck
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