Pharmacokinetic profiles of controlled-release hydrogel polymer vaginal inserts containing misoprostol.

@article{Powers2008PharmacokineticPO,
  title={Pharmacokinetic profiles of controlled-release hydrogel polymer vaginal inserts containing misoprostol.},
  author={Barbara L Powers and Deborah Ann Wing and Denis H. Carr and Karine Ewert and Mike Di Spirito},
  journal={Journal of clinical pharmacology},
  year={2008},
  volume={48 1},
  pages={26-34}
}
Misoprostol, a prostaglandin E1 analogue, is commonly administered intravaginally for cervical ripening and induction of labor. There is uncertainty regarding the correct dose because of the need to divide the tablets, and there is difficulty in removing the product when there is an adverse event. A proprietary hydrogel polymer containing a removable controlled-release reservoir dose of misoprostol is being developed for vaginal administration (misoprostol vaginal insert) to address these… CONTINUE READING
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