Pharmacokinetic profile of nicorandil in humans: an overview.

  title={Pharmacokinetic profile of nicorandil in humans: an overview.},
  author={Asher Frydman},
  journal={Journal of cardiovascular pharmacology},
  volume={20 Suppl 3},
  • Asher Frydman
  • Published 1992 in Journal of cardiovascular pharmacology
Nicorandil is rapidly and almost completely absorbed from the gastrointestinal tract. Nicorandil is not metabolized significantly by the liver during passage through the portal system (lack of first-pass effect). Thus, it easily enters the systemic blood flow, resulting in almost complete bioavailability (75-100%). The concomitant food intake decreases the rate of absorption of the drug, resulting in a delay of peak plasma concentration, but has little or no effect on maximal plasma… CONTINUE READING