Pharmacokinetic profile of meropenem, administered at 500 milligrams every 8 hours, in plasma and cantharidin-induced skin blister fluid.

@article{Maglio2003PharmacokineticPO,
  title={Pharmacokinetic profile of meropenem, administered at 500 milligrams every 8 hours, in plasma and cantharidin-induced skin blister fluid.},
  author={Dana Maglio and R. -J. Teng and Per T Thyrum and Charles H. Nightingale and David P Nicolau},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 5},
  pages={1771-3}
}
The pharmacokinetic disposition of meropenem, administered at 500 mg every 8 h, in plasma and cantharidin-induced blister fluid is described. Peak meropenem concentrations in blister fluid lagged behind peak meropenem concentrations in plasma, while a lower elimination rate from blister fluid was also noted. The mean penetration of meropenem into blister fluid was 67%. The pharmacokinetic profile of meropenem in blister fluid supports the utility of this dose in the management of skin and soft… CONTINUE READING

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