Pharmacokinetic profile of imipenem/cilastatin in normal volunteers.

  title={Pharmacokinetic profile of imipenem/cilastatin in normal volunteers.},
  author={George L. Drusano and Harold C. Standiford},
  journal={The American journal of medicine},
  volume={78 6A},
Imipenem is a new carbapenem antibiotic. It is coadministered with an equal amount of cilastatin, a dehydropeptidase-I inhibitor. Both drugs achieve similar serum concentrations in normal volunteers. Half-lives for both drugs are on the order of one hour and are excreted in the main into the urine. Cilastatin has been documented to have a metabolite, N-acetyl cilastatin, which can be recovered in the urine in an amount equivalent to approximately 12 percent of the administered dose of the… CONTINUE READING

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