Pharmacokinetic principles of bacteriophage therapy.

  title={Pharmacokinetic principles of bacteriophage therapy.},
  author={Robert J. H. Payne and Vincent A A Jansen},
  journal={Clinical pharmacokinetics},
  volume={42 4},
Use of bacteriophage to control bacterial infections, including antibiotic-resistant infections, shows increasing therapeutic promise. Effective bacteriophage therapy requires awareness of various novel kinetic phenomena not known in conventional drug treatments. Kinetic theory predicts that timing of treatment could be critical, with the strange possibility that inoculations given too early could be less effective or fail completely. Another paradoxical result is that adjuvant use of an… CONTINUE READING