Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.

  title={Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.},
  author={Peter Baumann},
  journal={Clinical pharmacokinetics},
  volume={31 6},
The recently introduced antidepressants, the selective serotonin reuptake inhibitors (SSRIs) [citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline], are known for their clinical efficacy, good tolerability and relative safety. They differ from each other in chemical structure, metabolism and pharmacokinetic properties. Therapeutic drug monitoring of these compounds is not widely used, as the plasma concentration ranges within which clinical response with minimal adverse effects… CONTINUE READING


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