Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration.

@article{Mandema1991PharmacokineticpharmacodynamicMO,
  title={Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration.},
  author={Jaap W. Mandema and Erica Tukker and Meindert Danhof},
  journal={British journal of pharmacology},
  year={1991},
  volume={102 3},
  pages={663-8}
}
1. The purpose of the present investigation was to quantify the concentration-pharmacological effect relationship of midazolam in individual rats by use of effect parameters derived from aperiodic EEG analysis. By varying the rate and route of administration the role of (inter)active metabolites and development of acute tolerance was evaluated. 2. The pharmacokinetics and pharmacodynamics of midazolam were determined after intravenous administration of 10 mg kg-1 during 5, 30 and 60 min and… CONTINUE READING