Pharmacokinetic-pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients.

@article{Wart2009PharmacokineticpharmacodynamicMT,
  title={Pharmacokinetic-pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients.},
  author={Scott A Van Wart and David R Andes and Paul G. Ambrose and Sujata M. Bhavnani},
  journal={Diagnostic microbiology and infectious disease},
  year={2009},
  volume={63 4},
  pages={409-14}
}
Dose regimen selection in late-phase clinical trials is critical for successful drug development, the well-being of individual patients, and given the ongoing emergence of antimicrobial resistance, society as a whole. Herein we describe some of the animal pharmacokinetics-pharmacodynamics, human pharmacokinetic, and in silico modeling work that was conducted in an effort to maximize the probability of a positive clinical response to therapy and minimize the likelihood for exposure-related… CONTINUE READING

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