Pharmacokinetic-pharmacodynamic modeling of the antilipolytic effects of an adenosine receptor agonist in healthy volunteers.

@article{Zannikos2001PharmacokineticpharmacodynamicMO,
  title={Pharmacokinetic-pharmacodynamic modeling of the antilipolytic effects of an adenosine receptor agonist in healthy volunteers.},
  author={Peter N. Zannikos and Shashank S Rohatagi and Bradford K Jensen},
  journal={Journal of clinical pharmacology},
  year={2001},
  volume={41 1},
  pages={61-9}
}
ARA is an adenosine receptor agonist with high affinity for A1 and A2 receptors, which are involved in regulation of free fatty acid (FFA) production. Two parallel groups of 13 healthy males were enrolled in a Phase I study to evaluate the pharmacokinetics of this compound and to characterize its effect on plasma FFA concentrations following administration of a single 6-hour intravenous infusion of ARA or placebo. ARA plasma concentrations were measured by a validated high-performance liquid… CONTINUE READING
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