Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers.

@article{Ragueneau1998PharmacokineticpharmacodynamicMO,
  title={Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers.},
  author={Isabelle Ragueneau and Christian Laveille and R. Jochemsen and Guillemette Resplandy and Christian Funck-Brentano and P. Jaillon},
  journal={Clinical pharmacology and therapeutics},
  year={1998},
  volume={64 2},
  pages={192-203}
}
OBJECTIVE Ivabradine (S-16257) is a new bradycardic agent with a direct effect on the sinus node. Its N-dealkylated metabolite, S-18982, has shown a bradycardic activity in animals. The aim of this trial was to study the correlation between drug bradycardic activity and plasma levels of the parent compound and its metabolite in healthy volunteers. METHODS Eighteen healthy volunteers participated in three successive study periods: an oral double-blind period with two parallel groups of doses… CONTINUE READING

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