Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteers.

@article{Hering1996PharmacokineticpharmacodynamicMO,
  title={Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteers.},
  author={Werner Hering and Harald Ihmsen and Harald Langer and C. Uhrlau and Michael Dinkel and Gerd 7 Geisslinger and J{\"u}rgen Sch{\"u}ttler},
  journal={Anesthesiology},
  year={1996},
  volume={85 6},
  pages={1290-9}
}
BACKGROUND In the last 4 y, several authors have reported largely satisfactory results using the new steroid intravenous anesthetic eltanolone (pregnanolone) to induce anesthesia. Until now, however, no investigations have addressed the infusion pharmacokinetics of eltanolone or used electroencephalographic effect data for full pharmacodynamic modeling. Thus the authors conducted a study to evaluate the pharmacokinetic and pharmacodynamic properties of eltanolone after infusion in healthy… CONTINUE READING