Pharmacokinetic-pharmacodynamic modeling of prednisolone-induced lymphocytopenia in man.

Abstract

The lymphocytopenic effect of prednisolone as quantified by OKT3- and OKT4-positive lymphocyte counts in peripheral blood was studied. Single oral prednisolone doses of 10, 30 and 60 mg, respectively, were given to three groups of five subjects. The time courses of prednisolone concentration and lymphocytopenic effects were related by a pharmacokinetic… (More)

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