Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors.

Abstract

The HMG-CoA reductase inhibitors (statins) are effective in both the primary and secondary prevention of ischaemic heart disease. As a group, these drugs are well tolerated apart from two uncommon but potentially serious adverse effects: elevation of liver enzymes and skeletal muscle abnormalities, which range from benign myalgias to life-threatening… (More)

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