Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegaly.

@article{Ma2005PharmacokineticpharmacodynamicCO,
  title={Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegaly.},
  author={Peiming Ma and Yanfeng Wang and Joost van der Hoek and Jerry R. Nedelman and Horst F Schran and L L Tran and Steven W. J. Lamberts},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={78 1},
  pages={69-80}
}
OBJECTIVE Acromegaly is a serious hormonal disorder resulting from a pituitary adenoma causing excess growth hormone (GH) production. Somatostatin analogs such as octreotide have been the medical treatment of choice. SOM230, a novel somatostatin analog, was compared with octreotide with respect to pharmacokinetic (PK) profiles and inhibition of GH secretion in acromegalic patients. METHODS In a double-blind, 3-period, crossover, proof-of-concept study, 12 patients with active acromegaly were… CONTINUE READING

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