Pharmacokinetic parameters of total and unbound valproic acid and their relationships to seizure control in epileptic children.

@article{Ayudhya2006PharmacokineticPO,
  title={Pharmacokinetic parameters of total and unbound valproic acid and their relationships to seizure control in epileptic children.},
  author={Duangchit Panomvana Na Ayudhya and Jintana Suwanmanee and Anainnit Visudtibhan},
  journal={American journal of therapeutics},
  year={2006},
  volume={13 3},
  pages={211-7}
}
The aims of this study were to define the relationship between total and unbound valproic acid (VPA) concentrations, to compare pharmacokinetic parameters of total and unbound VPA, and to determine the difference in pharmacokinetic parameters between the seizure-controlled and -uncontrolled groups. Total and unbound steady-state serum concentration of VPA were determined at trough and at 5 hours after the morning dose from 29 pediatric patients with epilepsy who were receiving valproic acid as… CONTINUE READING

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