Pharmacokinetic parameters of sisomicin.

  title={Pharmacokinetic parameters of sisomicin.},
  author={Burt R Meyers and Shalom Z. Hirschman and Stanley R Yancovitz and Bruce S. Ribner},
  journal={Antimicrobial agents and chemotherapy},
  volume={10 1},
Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 mug/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 mug/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters… CONTINUE READING

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