Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model

@article{Paudel2018PharmacokineticPE,
  title={Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model},
  author={Atmika Paudel and Suresh Panthee and Makoto Urai and Hiroshi Hamamoto and Tomohiko Ohwada and Kazuhisa Sekimizu},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we used the silkworm infection model to perform structure-activity relationship studies of an antimicrobial agent, GPI0039, a novel nitrofuran dichloro-benzyl ester, and successfully identified compound… Expand
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19 Citations

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