Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model

  title={Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model},
  author={A. Paudel and Suresh Panthee and M. Urai and H. Hamamoto and T. Ohwada and K. Sekimizu},
  journal={Scientific Reports},
  • A. Paudel, Suresh Panthee, +3 authors K. Sekimizu
  • Published 2018
  • Chemistry, Medicine
  • Scientific Reports
  • Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we used the silkworm infection model to perform structure-activity relationship studies of an antimicrobial agent, GPI0039, a novel nitrofuran dichloro-benzyl ester, and successfully identified compound… CONTINUE READING
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