Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome.

@article{Andersen2013PharmacokineticPD,
  title={Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome.},
  author={Erlend K. F. Andersen and Knut H{\aa}kon Hole and Kjersti Vassmo Lund and Kolbein Sundf\or and Gunnar Balle Kristensen and Heidi Lyng and Eirik Malinen},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2013},
  volume={107 1},
  pages={117-22}
}
PURPOSE To assess the prognostic value of pharmacokinetic parameters derived from pre-chemoradiotherapy dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of cervical cancer patients. MATERIALS AND METHODS Seventy-eight patients with locally advanced cervical cancer underwent DCE-MRI with Gd-DTPA before chemoradiotherapy. The pharmacokinetic Brix and Tofts models were fitted to contrast enhancement curves in all tumor voxels, providing histograms of several pharmacokinetic… CONTINUE READING

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