Pharmacokinetic parameters: which are necessary to define a drug substance?

  title={Pharmacokinetic parameters: which are necessary to define a drug substance?},
  author={Leslie Z Benet},
  journal={European journal of respiratory diseases. Supplement},
  • Leslie Z Benet
  • Published 1984 in
    European journal of respiratory diseases…
Pharmacokinetics describe what the body does to the drug, as opposed to pharmacodynamics which describe what the drug does to the body. Pharmacokinetic information is required to optimize the pharmacodynamic response. The primary pharmacokinetic disposition parameter is clearance. Knowledge of this value and its major constituent parts, i.e. fractional renal and hepatic elimination, allows the clinician to prescribe the correct dosage regimen to obtain a mean therapeutic concentration and to… CONTINUE READING