Pharmacokinetic optimisation of therapy with newer antidepressants.

  title={Pharmacokinetic optimisation of therapy with newer antidepressants.},
  author={Paul J Goodnick},
  journal={Clinical pharmacokinetics},
  volume={27 4},
Since the early 1950s, when imipramine was first introduced, a whole series of antidepressants with differences in structures, neurochemical effects and pharmacokinetics have been developed. Structurally or functionally, they have been classified as tricyclic antidepressants (TCAs), tetracyclic antidepressants, monoamine oxidase inhibitors (MAOIs), or selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs). In addition, there is a series of antidepressants with unique… CONTINUE READING


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