Pharmacokinetic optimisation of oral hypoglycaemic therapy.

  title={Pharmacokinetic optimisation of oral hypoglycaemic therapy.},
  author={Pablo A. Marchetti and Rosa Giannarelli and Anna Di Carlo and Renzo Navalesi},
  journal={Clinical pharmacokinetics},
  volume={21 4},
Two main classes of oral hypoglycaemic drugs, the sulphonylureas and the biguanides, are currently used in the therapy of type II, non-insulin-dependent diabetes mellitus (NIDDM). The basic pharmacokinetic properties of these agents are discussed with a view to efficient and safe treatment. Both first- and second-generation sulphonylureas are rapidly absorbed from the gastrointestinal tract. In the plasma compartment, these drugs are strongly bound to serum proteins. All sulphonylureas are… CONTINUE READING

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