Pharmacokinetic optimisation of general anaesthesia in pregnancy.

  title={Pharmacokinetic optimisation of general anaesthesia in pregnancy.},
  author={Tony Gin},
  journal={Clinical pharmacokinetics},
  volume={25 1},
  • Tony Gin
  • Published 1993 in Clinical pharmacokinetics
A significant proportion of women require general anaesthesia during pregnancy or for delivery. There are many practical difficulties in studying anaesthetic drugs and techniques to determine what may be best for both the mother and fetus. Physiological changes of pregnancy may alter the pharmacokinetics and pharmacodynamics of anaesthetics and the fetal disposition of drugs is largely unknown. With the limited pharmacokinetic data available, conclusions on the suitability of drugs are reached… CONTINUE READING