Pharmacokinetic optimisation of cancer chemotherapy. Effect on outcomes.

@article{Masson1997PharmacokineticOO,
  title={Pharmacokinetic optimisation of cancer chemotherapy. Effect on outcomes.},
  author={Edward Masson and William C. Zamboni},
  journal={Clinical pharmacokinetics},
  year={1997},
  volume={32 4},
  pages={324-43}
}
Cancer chemotherapy doses are empirical in that the majority are administered at a fixed dose (mg/m2 or mg/kg). One reason for this is the intrinsic sensitivity of the tumour or host cells to one particular chemotherapy agent is unknown. Therefore, the likelihood of response or toxicity is unpredictable a priori. This contrasts with antimicrobial… CONTINUE READING