Pharmacokinetic models for the saturable distribution of paclitaxel.

@article{Karlsson1999PharmacokineticMF,
  title={Pharmacokinetic models for the saturable distribution of paclitaxel.},
  author={Mats O. Karlsson and Val{\'e}ria Moln{\'a}r and Agneta Freijs and Patrik Nygren and Jennifer Bergh and Roger Larsson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 10},
  pages={
          1220-3
        }
}
Paclitaxel pharmacokinetics are nonlinear with saturable metabolism and saturable distribution to the tissues. The saturable distribution has in previous pharmacokinetic modeling been described as a saturable transport process, whereas the present study was undertaken to investigate alternative explanations. Using a sparse sampling scheme (on average 3.3 samples per profile), 101 plasma concentration-time profiles in 22 female patients with metastatic cancer of the breast or ovary were… CONTINUE READING
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