Corpus ID: 15571784

Pharmacokinetic models for the saturable distribution of paclitaxel.

  title={Pharmacokinetic models for the saturable distribution of paclitaxel.},
  author={M. Karlsson and V. Moln{\'a}r and A. Freijs and P. Nygren and J. Bergh and R. Larsson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={27 10},
  • M. Karlsson, V. Molnár, +3 authors R. Larsson
  • Published 1999
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological fate of chemicals
  • Paclitaxel pharmacokinetics are nonlinear with saturable metabolism and saturable distribution to the tissues. The saturable distribution has in previous pharmacokinetic modeling been described as a saturable transport process, whereas the present study was undertaken to investigate alternative explanations. Using a sparse sampling scheme (on average 3.3 samples per profile), 101 plasma concentration-time profiles in 22 female patients with metastatic cancer of the breast or ovary were… CONTINUE READING

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