Corpus ID: 15571784

Pharmacokinetic models for the saturable distribution of paclitaxel.

@article{Karlsson1999PharmacokineticMF,
  title={Pharmacokinetic models for the saturable distribution of paclitaxel.},
  author={M. Karlsson and V. Moln{\'a}r and A. Freijs and P. Nygren and J. Bergh and R. Larsson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 10},
  pages={
          1220-3
        }
}
  • M. Karlsson, V. Molnár, +3 authors R. Larsson
  • Published 1999
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological fate of chemicals
  • Paclitaxel pharmacokinetics are nonlinear with saturable metabolism and saturable distribution to the tissues. The saturable distribution has in previous pharmacokinetic modeling been described as a saturable transport process, whereas the present study was undertaken to investigate alternative explanations. Using a sparse sampling scheme (on average 3.3 samples per profile), 101 plasma concentration-time profiles in 22 female patients with metastatic cancer of the breast or ovary were… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 15 REFERENCES
    Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors.
    • 138
    • Highly Influential
    Paclitaxel pharmacokinetics and pharmacodynamics.
    • 126
    Taxol transport by human intestinal epithelial Caco-2 cells.
    • 84
    • Highly Influential
    • PDF
    Extensive and saturable accumulation of paclitaxel by the human platelet
    • 21
    • Highly Influential
    The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches
    • 295
    Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM.
    • 883