Pharmacokinetic models for propofol--defining and illuminating the devil in the detail.

@article{Absalom2009PharmacokineticMF,
  title={Pharmacokinetic models for propofol--defining and illuminating the devil in the detail.},
  author={Anthony R. Absalom and V. N. Deiva Mani and Tom De Smet and Michel M. R. F. Struys},
  journal={British journal of anaesthesia},
  year={2009},
  volume={104 2},
  pages={261-2; author reply 262-4}
}
The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting. With effect-site targeting the goal is to achieve a user-defined target effect-site concentration as rapidly as possible, by manipulating the plasma concentration around the target. Currently systems are pre-programmed with the Marsh and Schnider pharmacokinetic models for propofol. The former is an adapted version of the… CONTINUE READING