Pharmacokinetic modelling of blood-brain barrier transport of escitalopram in rats.

@article{Bundgaard2007PharmacokineticMO,
  title={Pharmacokinetic modelling of blood-brain barrier transport of escitalopram in rats.},
  author={Christoffer Bundgaard and Martin Heide J\orgensen and Frank Larsen},
  journal={Biopharmaceutics & drug disposition},
  year={2007},
  volume={28 7},
  pages={349-60}
}
This study examined the pharmacokinetics and distribution of escitalopram in the brain extracellular fluid in rats by the concurrent use of intracerebral microdialysis and serial blood sampling. Following three constant intravenous infusions, drug concentrations in the hippocampus and plasma were monitored for 6 h. To estimate the integrated pharmacokinetics and intercompartmental transport parameters, including blood-brain barrier (BBB) transport over the entire dose range, unbound brain and… CONTINUE READING

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