Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients.

Abstract

Several factors contribute to mycophenolic acid (MPA) between-patient variability. Here we characterize the metabolic pathways of MPA and quantify the effect of combining genetic polymorphism of multidrug-resistant-associated protein-2, demographics, biochemical covariates, co-medication (cyclosporine (CsA) vs. macrolides), and renal function on MPA, 7-O… (More)
DOI: 10.1038/ki.2013.517

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