Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine.

@article{McMullin2003PharmacokineticMO,
  title={Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine.},
  author={Tami S McMullin and Jill M Brzezicki and Brian K Cranmer and John D. Tessari and Melvin E. Andersen},
  journal={Journal of toxicology and environmental health. Part A},
  year={2003},
  volume={66 10},
  pages={941-64}
}
A physiological pharmacokinetic (PPK) model, with blood, body, and brain compartments, was developed to estimate total plasma chlorotriazine (CI-TRI) time courses (i.e., atrazine [ATRA] and its three chlorinated metabolites) after oral dosing with ATRA. The model, based on disposition data for 14C-ATRA, tracked two pools of compounds: (1) ATRA and chlorinated metabolites (i.e., the CI-TRIs) and (2) glutathione conjugates. The PPK model developed from total radioactivity was valuable for… CONTINUE READING

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