Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials.

@article{Rivory1997PharmacokineticIO,
  title={Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials.},
  author={Laurent P. Rivory and M. C. Haaz and Pierre Canal and François M. Lokiec and Jean Pierre Armand and J. Robert},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1997},
  volume={3 8},
  pages={1261-6}
}
Irinotecan (CPT-11) is an analogue of 20(S)-camptothecin with promising activity against several tumor types. In patients, CPT-11 is metabolized to 7-ethyl-10-hydroxycamptothecin (SN-38) and to the beta-glucuronide of SN-38. Recently, we identified an additional metabolite of CPT-11, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin (APC; L. P. Rivory et al. , Cancer Res., 56: 3689-3694, 1996). The aim of this study was to investigate the interrelationships of all… CONTINUE READING
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Synthesis and antitumor activity of 20(S)-carnptothecin derivatives: carbamatelinked, water-soluble derivatives of 7-ethyl-lO-hydroxycamptothecin

  • S. Sawada, S. Okajirna, +6 authors T. Miyasaka
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