Pharmacokinetic interactions with antiepileptic drugs.

  title={Pharmacokinetic interactions with antiepileptic drugs.},
  author={Emilio Perucca},
  journal={Clinical pharmacokinetics},
  volume={7 1},
A large number of pharmacokinetic interactions with antiepileptic drugs have been reported in recent years. Among the interactions affecting the disposition of anticonvulsants, the most important are probably those resulting in inhibition of the metabolism of phenytoin, phenobarbitone and carbamazepine. Drugs which have been shown to inhibit the metabolism of these anticonvulsants and to precipitate clinical signs of intoxication in epileptic patients include sulthiame, valproic acid… CONTINUE READING
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