Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs

@article{Lee2012PharmacokineticIO,
  title={Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs},
  author={Joo H. Lee and Yong-Jun Shin and Ju-Hee Oh and Young-Joo Lee},
  journal={Archives of Pharmacal Research},
  year={2012},
  volume={35},
  pages={1831-1837}
}
In this study, we investigated pharmacokinetic drug interactions of clopidogrel with P-gp inhibitors in rats and dogs. Following the oral administration of clopidogrel with or without the P-gp inhibitors, quercetin (250 mg/kg), telmisartan (8 mg/kg), and cyclosporine A (10 mg/kg), in rats and dogs, the plasma concentration-time profiles of clopidogrel carboxylic acid, a surrogate marker for the bioavailability of clopidogrel, were determined. Co-administration of the quercetin, telmisartan and… 

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References

SHOWING 1-10 OF 33 REFERENCES

Effects of cyclosporin A and itraconazole on the pharmacokinetics of atorvastatin in rats

TLDR
It is indicated that cyclosporin A could be effective in inhibiting the efflux of atorvastatin, and itraconazole could beeffective in inhibition of both the metabolism and biliary excretion of atorsportatin.

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.

TLDR
Concomitant administration of rifampin reduced digoxin plasma concentrations substantially after oral administration but to a lesser extent after intravenous administration, and induction of intestinal P-gp could explain this new type of drug-drug interaction.

Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats

  • J. H. LeeH. KangM. Lee
  • Biology, Medicine
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2010
TLDR
After the oral and intravenous administration of both drugs together, the total area under the plasma concentration–time curve (AUC) of metformin was comparable possibly due to the increased intestinal metabolism of met formin by telithromycin.

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs

TLDR
The extent of in vivo formation of the thiolactone and the active metabolite of prasugrel was greater than for clopidogrel’s thiolactsone and active metabolites, which demonstrates that these products are generated in the intestine during the absorption process.

Modest Effect of Impaired P-glycoprotein on the Plasma Concentrations of Fexofenadine, Quinidine, and Loperamide following Oral Administration in Collies

TLDR
It is suggested that P-gp limits the intestinal absorption of fexofenadine in dogs, and the Mdr1 mutation will be useful for examining the effect of P- gp on the oral availability of drugs.

Cytochrome P450 3A Inhibition by Ketoconazole Affects Prasugrel and Clopidogrel Pharmacokinetics and Pharmacodynamics Differently

TLDR
CYP3A4 and CYP3A5 inhibition by ketoconazole affects formation of clopidogrel's but not prasugrel's active metabolite, which is associated with reduced IPA.

The Effect of Telmisartan on the Steady‐State Pharmacokinetics of Digoxin in Healthy Male Volunteers

TLDR
Although there was some evidence for a pharmacokinetic interaction between digoxin and telmisartan found in this study, the safety and tolerability of digoxin were unaffected by concurrent administration of tel Misartan in the study population.

Intra-herb pharmacokinetics interaction between quercetin and isorhamentin

TLDR
P-gp might play an important role, whereas other drug efflux pumps, such as multi-drug resistance associate protein 2 and breast cancer resistance protein, might be involved in the cell efflux of isorhamnetin.