Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs

@article{Lee2012PharmacokineticIO,
  title={Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs},
  author={Joo H. Lee and Yong-Jun Shin and Ju-Hee Oh and Young-Joo Lee},
  journal={Archives of Pharmacal Research},
  year={2012},
  volume={35},
  pages={1831-1837}
}
In this study, we investigated pharmacokinetic drug interactions of clopidogrel with P-gp inhibitors in rats and dogs. Following the oral administration of clopidogrel with or without the P-gp inhibitors, quercetin (250 mg/kg), telmisartan (8 mg/kg), and cyclosporine A (10 mg/kg), in rats and dogs, the plasma concentration-time profiles of clopidogrel carboxylic acid, a surrogate marker for the bioavailability of clopidogrel, were determined. Co-administration of the quercetin, telmisartan and… 
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