Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir.

  title={Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir.},
  author={G. Muirhead and Maria B Wulff and Anitra Fielding and Diane Kleinermans and Neil Buss},
  journal={British journal of clinical pharmacology},
  volume={50 2},
AIMS To investigate the effect of the antiretroviral protease inhibitors saquinavir (soft gelatin capsule) and ritonavir on the pharmacokinetic properties and tolerability of sildenafil and to investigate the effect of sildenafil on the steady-state pharmacokinetics of saquinavir and ritonavir. METHODS Two independent, 8 day, open, randomized, placebo-controlled, parallel-group studies (containing a double-blind crossover phase) were conducted at Pfizer Clinical research units (Canterbury, UK… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 26 references

Sildena®l. A review of its use in erectile dysfunction

HD Langtry, A. Markham
Drugs • 1999

Changing patterns of mortality across Europe in patients infected with HIV - 1

A Mocroft, S Vella, TL Ben®eld
Lancet • 1998

Clinical pharmacology and ef®cacy

S Vella, Floridia M. Saquinavir
Clin Pharmacokin • 1998

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