Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047.

@article{Fichtenbaum2002PharmacokineticIB,
  title={Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047.},
  author={Carl J. Fichtenbaum and John G. Gerber and Susan L. Rosenkranz and Yoninah Segal and Judith Aberg and Terrence F. Blaschke and Beverly L Alston and Fang Fang and Bradley W Kosel and Francesca T. Aweeka},
  journal={AIDS},
  year={2002},
  volume={16 4},
  pages={569-77}
}
OBJECTIVE Lipid lowering therapy is used increasingly in persons with HIV infection in the absence of safety data or information on drug interactions with antiretroviral agents. The primary objectives of this study were to examine the effects of ritonavir (RTV) plus saquinavir soft-gel (SQVsgc) capsules on the pharmacokinetics of pravastatin, simvastatin, and atorvastatin, and the effect of pravastatin on the pharmacokinetics of nelfinavir (NFV) in order to determine clinically important drug… CONTINUE READING

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