Pharmacokinetic interactions between HIV-protease inhibitors in rats.

  title={Pharmacokinetic interactions between HIV-protease inhibitors in rats.},
  author={H Yamaji and Yasuo Matsumura and Yukako Yoshikawa and Kanji Takada},
  journal={Biopharmaceutics & drug disposition},
  volume={20 5},
The interactions of four HIV-protease inhibitors, ritonavir (RIT), saquinavir (SAQ), indinavir (IND) and nelfinavir (NEL), were examined by in vitro metabolic studies using rat liver microsomal fractions. The substrate concentrations employed were 0.75 approximately 12 microM, and the inhibitor concentrations were 2.5 approximately 60 microM. The metabolic clearance rates of SAQ, NEL and IND as determined by V(max)/K(m) were 170.9+/-10.9, 126.0+/-4.4 and 73.0+/-2.0 microL/min/mg protein… CONTINUE READING

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