Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.

@article{Kusuhara2012PharmacokineticIS,
  title={Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.},
  author={Hiroyuki Kusuhara and Hidetoshi Furuie and Akihiro Inano and Akihiro Sunagawa and Saiko Yamada and C. Wu and Shinya Fukizawa and Nozomi Morimoto and Ichiro Ieiri and Mariko Morishita and Kiminobu Sumita and Hiroshi Mayahara and Takuya Fujita and Kiyoshi Maeda and Yuichi Sugiyama},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 6},
  pages={1793-803}
}
BACKGROUND AND PURPOSE An ATP-binding cassette (ABC) transporter, breast cancer resistance protein (BCRP)/ABCG2, limits oral bioavailability of sulphasalazine. Here we examined the effect of curcumin, the principal curcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses of sulphasalazine in humans. EXPERIMENTAL APPROACH Effects of curcumin were measured on the ATP-dependent sulphasalazine uptake by hBCRP-expressing membrane vesicles and on oral bioavailability of… CONTINUE READING

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