Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects

@article{Priskorn1997PharmacokineticIS,
  title={Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects},
  author={M. Priskorn and Finn Larsen and Alain Segonzac and Marcelle Moulin},
  journal={European Journal of Clinical Pharmacology},
  year={1997},
  volume={52},
  pages={241-242}
}
Citalopram is an antidepressant belonging to a class of drugs that selectively and potently inhibits serotonin reuptake into central neurones [1]. Cimetidine inhibits the activity of the cytochrome P450 enzyme system [2], in particular the CYP2D6, CYP3A4 and CYP1A2 isozymes [3]. Demethylation of citalopram to form demethylcitalopram (DCT) appears to be mediated via CYP2C19, while the further demethylation of DCT to form didemethylcitalopram (DDCT) appears to a large extent to be mediated via… CONTINUE READING