Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance.

@article{Takahashi1999PharmacokineticIB,
  title={Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance.},
  author={Harumi Takahashi and Toshitaka Kashima and Sumihisa Kimura and Nanae Murata and Toshihiro Takaba and Kazunori Iwade and Takaaki Abe and Hitoshi Tainaka and Toshio Yasumori and a H Echizen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 10},
  pages={1179-86}
}
A uricosuric agent, bucolome, has been shown to intensify the anticoagulant effect of warfarin. The aims of the present study were to clarify its mechanism(s) and to apply in vitro approaches for predicting this potentially life-threatening in vivo interaction. An in vivo study revealed that Japanese patients given warfarin with bucolome (300 mg/day, n = 21) showed a 1.5-fold greater international normalized ratio than those given warfarin alone (n = 34) despite that the former received a 58… CONTINUE READING