Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects

@article{Dutreix2004PharmacokineticIB,
  title={Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects},
  author={Catherine Dutreix and Bin Peng and Guenther H. Mehring and Michael J. Hayes and Renaud Capdeville and Rolf Pokorny and Michael K Seiberling},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={54},
  pages={290-294}
}
The study under discussion was a drug–drug interaction study in which the effect of ketoconazole, a potent CYP450 3A4 inhibitor, on the pharmacokinetics of Glivec (imatinib) was investigated. A total of 14 healthy subjects (13 male, 1 female) were enrolled in this study. Each subject received a single oral dose of imatinib 200 mg alone, and a single oral dose of imatinib 200 mg coadministered with a single oral dose of ketoconazole 400 mg according to a two-period crossover design. The… CONTINUE READING