Pharmacokinetic interaction between high-dose methotrexate and amoxycillin.

  title={Pharmacokinetic interaction between high-dose methotrexate and amoxycillin.},
  author={Crisanto L. Ronchera and Teodoro Hern{\'a}ndez and Jos{\'e} Esteban Peris and Ferran Torres and Luis Granero and N. V{\'i}ctor Jim{\'e}nez and Jorge Pla},
  journal={Therapeutic drug monitoring},
  volume={15 5},
A case report of toxicity following concurrent administration of high-dose methotrexate and amoxycillin is presented. A 16-year-old male patient was administered 10 high-dose methotrexate cycles for treatment of a fully malignant osteogenic sarcoma. Methotrexate was administered at a dosage of 8 g/m2 and infused intravenously over a 6-h period. The patient received pre- and posttreatment hydration and sodium bicarbonate for alkalinization of urine. Calcium folinate rescue was performed when… CONTINUE READING


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