Pharmacokinetic interaction between fluoxetine and omeprazole in healthy male volunteers: a prospective pilot study.

@article{Vlase2010PharmacokineticIB,
  title={Pharmacokinetic interaction between fluoxetine and omeprazole in healthy male volunteers: a prospective pilot study.},
  author={Laurian Vlase and Maria Adriana Neag and Adina Popa and Dana Maria Muntean and Sorin Emilian Leucuţa},
  journal={Current therapeutic research, clinical and experimental},
  year={2010},
  volume={71 6},
  pages={360-8}
}
BACKGROUND Fluoxetine is an inhibitor of the main metabolizing enzymes (cytochrome P450 [CYP] 2C19 and CYP3A4) of omeprazole and thus might influence that drug's pharmacokinetics. The changes in omeprazole's pharmacokinetics may have clinical significance concerning efficacy and tolerability of the treatment. OBJECTIVE The aim of this study was to assess the pharmacokinetic interaction of fluoxetine with omeprazole in healthy volunteers. METHODS The study enrolled healthy adult men and… CONTINUE READING