Pharmacokinetic interaction between DA‐8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2

@article{Choi2008PharmacokineticIB,
  title={Pharmacokinetic interaction between DA‐8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2},
  author={Y. H. Choi and Suk Jae Chung and Myung Gull Lee},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 7},
  pages={1568-78}
}
BACKGROUND AND PURPOSE Erectile dysfunction is highly prevalent in diabetic patients and PDE V inhibitors are effective and safe for the treatment of erectile dysfunction in men with diabetes. Therefore, in this study we investigated whether a pharmacokinetic interaction occurs between DA-8159 and metformin, as both drugs are metabolized via hepatic CYP3A1/2 in rats. EXPERIMENTAL APPROACH DA-8159 (30 mg kg(-1)) and metformin (100 mg kg(-1)), both separately and together, were administered to… CONTINUE READING

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